Bioremediation and Environmental Biotechnology
The BFF has optimized processes and made products for companies involved with bioremediation, including products for degrading nerve agents and products for decontamination of ground water. We can offer a number of services to clients involved in bioremediation and environmental biotech.
- Molecular biology services including gene optimization, cloning and transformation to generate ideal expression hosts.
- Fermentation Optimization: Our Das-Gip fed-batch Pro 8 reactor system is ideal for early stage development of process conditions and media. Our suite of New Brunswick Bioflo 3000 units is equally suited to this task.
- Growth of native or recombinant cultures from 750 ml to 800 L with typically short lead times of 1 to 3 weeks from the placement of orders.
- Downstream processing optimization: Development of centrifugation, TFF and other methods from bench to pilot scale.
- Harvesting of cultures and initial purification through centrifugation, TFF and other physical methods.
- Product purification optimization: development of purification methods for cells, proteins, peptides, viruses, metabolites and other biological products through physical, chemical, and chromatographic methods.
- A dedicated fill/finish suite is set up to bottle products aseptically and shelf lyophilizers and spray dryers are available to dry proteins, peptides and other products. Labeling is also available.
- A dedicated well equipped analytical lab is used to ensure product purity and quality meets client specifications.
Track Record
The BFF has optimized processes for the production of a range of bioremediation and environmental products, increasing yields and decreasing production costs. We have produced materials for lab and field testing.
We have assisted clients with technical transfer packages for moving production into large scale contract manufacturing plants.